Wednesday 25 April 2007

My summer project

My project title is:
"Species (MMP) transport in an abdominal aortic aneurysm with a porous ILT."

A quick vocab guide might be of use to those who do not have a clue what that means...
MMPs are Matrix-metalloproteinases. I'm not entirely sure what they are, but I have a feeling they're tricky buggers.
An aneurysm is when your artery swells up like a balloon due to a problem in the artery wall (usually thinning caused either by age or by an accident). The aorta is the main artery going from your heart up and round and then down towards your legs. Aneurysms may rupture and when they do the chances of survival are not good. Abdominal aortic aneurysms are known as AAAs or Triple-As.
ILT is an Intraluminal Thrombus. A thrombus is a blood clot. Intraluminal means it's within a structure (so within the artery).
Hemodynamics is the study of the flow of blood.

Overall agreed objectives:

Write a medical review of AAAs including MMP influence.

Write a scientific review of AAAs including hemodynamics, experimental and computer models.

Develop a simple steady flow model of a AAA with a porous thrombus and mass transport.

Develop a simple pulsatile flow model of a AAA with a porous thrombus and mass transport.

Mesh a realistic model taken from segmented CT images.

Incorporate the simplified anatomical model developed above into the realistic anatomical model.

Analysis of interactions between the thrombus, blood, and the artery wall with respect to AAA progression.

Deliverable(s):
1. A simple CFD model of AAA mass transport in steady flow with a porous ILT.
2. A simple CFD model of AAA mass transport in pulsatile flow with a porous ILT.
3. A realistic model of AAA mass trans port in pulsatile flow with a porous ILT.
4. A project report

I'll be using ANSYS FLUENT to model the aneurysm in 2D and 3D. The 3D version will come from a CT scan from a real-live poorly person. I hope that they got patched up okay and are still alive.

I expect to be very busy this summer. The project is due to start at the beginning of June. Before then I am going to have to do some medical reading. I'm really excited about this project. It sounds really cool (and hard work) and interesting.

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